“The Impact of Informant-Related Characteristics Including Sex/Gender on Assessment of Alzheimer’s Disease Symptoms and Severity.”

We are delighted to announce our latest opinion article in Frontiers in Global Women’s Health titled, “The Impact of Informant-Related Characteristics Including Sex/Gender on Assessment of Alzheimer’s Disease Symptoms and Severity.”

 

Did you know that the Clinical Dementia Rating Scale (CDR) is pivotal in Alzheimer’s disease (AD) staging?

 

Have you ever wonder which is the impact of the gender of caregiver characteristics on its readout?

 

Here we discussed how this factor —often overlooked—play a crucial role in the accuracy of this assessment.

 

Key Takeaways on possible biases:

Dynamics: The informant’s relationship with the patient can significantly affect the perception of the patient’s health status, potentially influencing severity scores.

Sex/Gender Influence: The sex/gender of the informant can also influence dementia assessments in significant ways.

Cultural Lens: Cultural and socioeconomic characteristics can influence how caregivers assess AD symptoms and severity.

These factors are vital in understanding caregiver reports and ensuring precise patient diagnosis and staging, especially when used as primary endpoints in clinical trials.

 

A heartfelt thank you to the brilliant minds behind this work: Ella Abken,  Laura Castro, Antonella, Maria Teresa Ferretti, and Carmela Tartaglia for their invaluable collaboration. 👏 

 

#AlzheimersResearch #WomensBrainHealth #NeurodegenerativeDiseases #ClinicalDementiaRating #HealthcareInnovationbias

 

🤝Donate today to support the advancement of brain and mental health: https://www.womensbrainproject.com/donate/

 

Link to the publication: https://www.frontiersin.org/articles/10.3389/fgwh.2024.1326881/full

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We are here to transform medicine and healthcare towards precision medicine. Right now, there is a critical need for your support. Donate today and help us continue to study Sex and Gender differences impacting brain and mental diseases.

Health begins with human beings, individuals – men and women are different when it comes to brain and mental disease frequency, severity, symptomatology, risk factors and even response to treatments. Thanks to the gifts from supporters like you the scientific community is starting to take note. We have shown the world that in diseases like Alzheimer’s for instance, disease progression is faster in women than men and women show different levels of biomarkers.

Our goal is to clearly identify such differences in diseases, diagnostic, and treatments, as well as novel technologies, and leverage them for better solutions. We ask for better clinical outcomes, better care, and innovative artificial intelligence (AI)-based solutions. Sex and gender differences are the first steps towards precision medicine, which acknowledges the specific needs of each patient. Our ultimate ambition is the realisation of the Research Institute for Sex and Gender Precision Medicine.